ABSTRACT:

This paper aims to provide researchers with a computational background, a comprehensive discussion on the importance of miRNA (microRNA), the related high-throughput technology and databases, the current development of computational algorithms for elucidating miRNA regulatory functions, and the prospective directions on related topics. Some topics discussed were about miRNA target recognition, silencing, expression profiling, transfection experiments, target predictions, databases, microarray data, biochemical approaches, rule-based algorithms, data-driven algorithms, prediction algorithms, transcription factors, and other computational techniques.